Tan Bin
2010
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Journal
Applied Chemical Industry
Abstract
2-(2-Fluorophenyl)-3,5-dimethyl-2-morpholinol hydrochloride was synthesized from 2-bromo-1-(2-fluorophenyl)-1-propanone via aminnation and cyclization in nonproton polar solvent,at last acidification by divergent synthetic method,with yield of 82.7%.Its structures was confirmed on by IR and 1H NMR.The synthetic route has the advantages of easy operation,mild reaction condition,short reaction time and high yield.