L. Liang
2000
Citations
0
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Citations
Journal
Fine chemicals
Abstract
Methoxyethoxy)acetaldehyde diethyl acetal, an important intermediate for the semi synthesis of macrolide antibiotics, was prepared by dissolving metallic sodium in methoxyethanol and immediately condensing with bromoacetaldehyde diethyl acetal. The drawback of the old method to use the expensive and dangerous material sodium hydride was avoided. The optimum reaction conditions were obtained by orthogonal test:molar ratio of metallic sodium to bromoacetaldehyde diethyl acetal was 1∶1 5, amount of solvent 0 36mL/mmol, reaction time 10h. The yield was 91 7%. The reaction was easier to control and the cost was lower. This new method is more suitable for the industrial production.