Q. Cheng
2006
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Journal
Chemical Reagents
Abstract
A new synthesis method of 2,3,4,5-tetramethoxytoluene was devised by using 4-methyltoluene which is easily available in industry.4-methyltoluene being catalyzed by Fe powder,gave high yields of 2,3,6-tribromic4-methyl-phenol,which when being added into sodium methoxide solution and catalyzed by cuprous chloride resulted in 2,3,4,5-tetramethoxytoluene with a yield of 95%.The yield can be optimized by varying the reaction temperature and the sodium methoxide concentration.