Tong Gang-sheng
2008
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Journal
Fine chemicals
Abstract
2,3,4-Trimethoxy-6-methylphenol was synthesized from 3,4,5-trimethoxytoluene through Vilsmeier-Haack reaction and Dakin reaction.The optimal conditions of Dakin reaction were n(6-methyl-2,3,4-trimethoxy-benzaldehycle)∶n(H2O2)=0.83∶1,p-toluenesulfonic acid as catalyst,reaction temperature 25 ℃,reaction time 2 h and w(H2O2)=30% in trickling rate of 0.1 mL/min.Under the optimal conditions,a yield of 96.2% was obtained.The two-step yield was 90.5%.