Zhao Tian-sheng
2010
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Journal
Chinese Journal of Pharmaceuticals
Abstract
2,3,4-Trimethoxybenzoic acid,the intermediate of trimetazidine,was synthesized from pyrogallol by methylation with dimethyl carbonate,bromination with NBS and cyanidation with CuCN to give 2,3,4-trimethoxybenzonitrile,followed by hydrolysis with an overall yield of about 38%.