Liu Chuan-xiang
2006
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Journal
Chinese Journal of New Drugs
Abstract
Objective:To synthesize 2-(3',5'-difluorophenyl)-3,5-dimethyl-2-morpholinol hydroehloride.Methods:The target compound was synthesized from 3,5-difluoropropiophenone as a start- ing agent via several steps including bromination,amination,cyclization and acidification.Results:The total yield of the target compound was 77.3%.The structures were verified using IR and H~1-NMR spec- tra.Conclusion:The halogen substituent toα-H of arylalkyketone with cupric bromide was much highly selective.The amination in nonproton polar solvent without toxicity shortens reaction time.