Zhu Hong-ji
2007
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Journal
China Medical Herald
Abstract
Objective:To prepare 2,3,6-trimethyl-7-amino-pyrazolo-[1,5-a]pyrimidine by the reaction of 3-amino-4,5-dimethyl-pyrazole with 3,3-dimethoxy-2-methyl-propanenitrile.Methods:At 75℃ for 8 hours in the presence of ethanol and acetic acid,cyclization reaction was carried out smoothly.Results:Total yield of 42.2% was obtained.The title compound was haracterized by 1H-NMR,IR,GC-MS and elementary analysis.Conclusion:The preparation method of 2,3,6-trimethyl-7-amino-pyrazolo-[1,5-a]pyrimidine is more available with a mild reaction condition and a good yield.