D. Hong
2006
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Journal
Fine Chemical Intermediates
Abstract
2,3-Dichlorobenzoic acid is the key intermediate for antiepileptic drug lamotrigine and the other medicine for the treatment of central nervous system (CNS)disorders and disease. 2,3-Dichlorobenzoic acid was prepared through diazotization and Meerwein reaction to give 2,3-dichlorobenzaldehyde from 2,3-dichloroaniline and followed by oxidation with potassium permanganate,and the overall yield was 45%. In addition,each operation of the reactions and purification was also studied .