H. Itazaki, A. Kawasaki, M. Matsuura
Sep 25, 1988
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0
Influential Citations
5
Citations
Quality indicators
Journal
Chemical & pharmaceutical bulletin
Abstract
In order to study new sulfonamide diuretics, two series of 6- and 5-sulfamoyl-2, 3-dihydro-1, 4-benzodioxins were synthesized and tested for diuretic and antihypertensive activities in rats. Starting from 4-chloro(or 3, 4-dichloro)-1, 2-dihydroxybenzene, these sulfamoyl compounds were prepared by two different routes. In method A, 6-sulfamoyl compounds (8 or 11) were obtained by conversion of the nitro function into sulfonamide via the Sandmeyer reaction. In method B, 5-sulfamoyl compounds (16) were synthesized by direct introduction of sulfonyl chloride into the dihydrobenzodioxin, followed by amination. The sulfamoyl dihydrobenzodioxins showed lower diuretic and antihypertensive activities than trichloromethiazide.