Ryoya Miura, Shin-ichi Goto, Takahide Hashimoto
Jun 16, 2020
Citations
0
Influential Citations
3
Citations
Journal
ACS Omega
Abstract
Synthesis of 2,3-disubstituted 4-ethoxycarbonyl-β-carbolin-1-ones is developed using palladium-catalyzed intramolecular amination of 3-amino-4-(2-bromophenyl)-2-pyridones prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl imines. The method was applied to the total syntheses of SL651498 exhibiting anxiolytic activity and its analogue.