R. Maleski, C. Osborne, S. Cline
Dec 1, 1991
Citations
0
Influential Citations
10
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
2(3H)-Benzoxazolones 3 can be prepared directly from the corresponding 2-aminophenols and phenyl chloroformate. The intermediate 2-hydroxy phenylcarbamates 2 are formed easily in aqueous alcohol solvent and these are converted rapidly to product, without their isolation, using one equivalent of sodium hydroxide. The synthesis accommodates a wide variety of substituents, including the easily hydrolyzed ethyl ester.