Li Gu-ca
2014
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Journal
Journal of Hunan Institute of Engineering
Abstract
2-[4-(4-Hydroxylbenzyl) piperazin-1-ylmethyl]pyrazolo[1,5-α]pyridine is synthesized from pyrazolo[1,5-α]pyridine-2-carbaldehyde,l-piperazinearboxaldehyde and 4-hydroxylbenzaldehyde through a three-step procedure.The structures of the intermediates and the target compound are confirmed by 1H NMR and ESI MS.Through vitro activity assay,the affinity constants of the target compound are determined to be 4200,2590,2.2 nM for D_2,D_3,D_4 receptor respectively.It suggests that 2-[4-(4-hydroxylbenzyl)piperazin-1-ylmethyl]pyrazolo[1,5-α]pyridine is a potential dopamine D_4 receptor ligand.