Cheng Qing-rong
2011
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Chemical Reagents
Abstract
2-(4-Bromomethylphenyl) propionic acid was synthesized from p-methybenzyl cyanide via methylation,hydrolysis and bromide reaction and ethyl 2-(4-bromomethylphenyl)propionate was synthesized from ethyl p-tolylacetate via methylation and bromide reaction.The influences of reaction time and phase transfer catalyst PEG were discussed on methylation.The result indicates that the optimum reaction time is 8 h for methylation,the optimum reaction temperature is 180 ℃ for p-methybenzyl cyanide and 220 ℃ for ethyl p-tolylacetate.The catalytic effect of methylation was obtained optimally with the synergistic catalysis of K2CO3 and PEG-400 for the former and the synergistic catalysis of K2CO3 and PEG-600 for the latter.Yield of the former from p-methybenzyl cyanide is 67.6% and yield of the latter from Ethyl p-tolylacetate is 74.8%.