Zhang Ai-hua
2008
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Journal
Fine Chemical Intermediates
Abstract
2-(4-Bromomethylphenyl)propionic acid which was a key intermediate of loxoprofen was synthesized from toluene through four reaction steps including Friedel-Crafts reaction, Willgerodt-Kindler-hydrolysis, monomethylation and bromination. The results showed that the reaction process of Friedel-Crafts and Willgerodt-Kindler-hydrolysis was promoted via ultrasonic, high-yield of ɑ-monomethylation product was obtained by complex phase transfer catalysisis, and overall yield was 55.1% , indicating that this was an efficient synthetic route with convenient operations and available reagents.