J. Mason, D. J. Milner
Feb 1, 1994
Citations
0
Influential Citations
2
Citations
Journal
Synthetic Communications
Abstract
Abstract Nitration of inexpensive 1,2,4-trichlorobenzene gave 2,4,5-trichloronitrobenzene (90%) which was treated with KF to form 2,4-difluoro-5-chloronitrobenzene (70%). This was selectively hydrogenated over Pd/C to give 2,4-difluoroaniline (80%). Deamination afforded 1,3-difluorobenzene. The sequence avoids the need for costly 1,3-dichlorobenzene.