N. Kundu, B. Das, A. Majumdar
Jul 24, 1990
Citations
0
Influential Citations
5
Citations
Journal
ChemInform
Abstract
A simple synthesis of 2,4-dimethoxy-5-(3-oxoalkynyl)pyrimidines from the readily available 5-ethynyl-2,4-dimethoxypyrimidine is described. The sequence proceeds via an ethynylboron intermediate which is acylated with carboxylic anhydrides. The 5-(3-oxo-1-alkynyl) products are hydrogenated to the saturated analogs and these are O-dealkylated with chlorotrimethylsilane/sodium iodide to give 5-(3-oxohexyl)uracil. These compounds and the nucleosides derived threrefrom are of interest as anticancer and antiviral agents