Yueqin Li, Guangqiang Lv, W. Yuqi
May 1, 2016
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Abstract
2,5-hexanedione, a valuable platform chemical which is being broadly used in biofuel, medicinal chemistry and drug discovery, was synthesized from biomass derived dimethyl furane using a highly efficient biphasic system. In this biphasic systems, mineral acids (HCl, H2SO4 and H3PO4) dissolved in aqueous phase were used as hydrolysis catalysts. The hydrolysis reaction is suggested to take place at the interface between the aqueous and the organic phase. But more importantly, water-immiscible organic phase could continuously extract the in-situ produced 2,5-hexanedione from the interface to prevent the extended contact between the 2,5-hexanedione and the acids, thereby avoiding the oligomerization side reactions A yield of 99 % could be obtained when methyl isobutyl ketone (MIBK) was the organic phase in the biphasic system.