L. Akella, R. Vince
Jun 17, 1996
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron
Abstract
Abstract The enantioselective synthesis of 2-[5-(9 H -purin-9-yl)-2-cyclopenten-1-yl]ethanol analogues is described. (1R,5R)-[1-( tert -butyldimethylsilyloxy)ethyl]-2-cyclopenten-5-ol 4a and (1S,5S)-[1-( tert -butyldimethylsilyloxy)ethyl]-2-cyclopenten-5-ol 4b were coupled with 6-chloropurine and 2-amino-6-chloropurine using Mitsunobu reaction conditions. Compounds 6a & b, 7a & b, 8a & b, 9a & b , and 10a & b were tested for antiviral activity.