K. Ramalingam, D. Ramesh, B. Sreenivasulu
2019
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Journal
Rasayan Journal of Chemistry
Abstract
Several derivatives of 2-[(5-aryl-1,3,4-oxadiazol-2-yl)thio]-N-(2-phenyl-1,8-naphthyridin-3-yl)acetamides and also 2-[substituted-(1H-benzo[d]imidazol-2-yl)thio]-N-(2-phenyl-1,8-naphthyridin-3-yl)acetamide derivatives were synthesized starting from the common intermediate 2-chloro-N-(2-phenyl-1,8-naphthyridin-3-yl)acetamide and its reaction with 5-aryl-1,3,4-oxadiazole-2-thione or appropriate 1H-benzo[d]imidazole-2-thiols, respectively. All newly synthesized compounds were elucidated by IR, NMR, Mass spectra and elemental analysis. The titled compounds were examined for their antibacterial activity and found to be with significant activity.