Nisaraporn Suthiwangcharoen, C. Stephens
Jan 30, 2007
Citations
0
Influential Citations
3
Citations
Journal
Arkivoc
Abstract
A new 3-step synthesis of 2,5-bis(4-cyanophenyl)furan, a key intermediate in the preparation of the antimicrobial agents Furamidine and Pafuramidine, is presented. The key step of the synthesis is the preparation of a 1,4-diketone via the modified Stetter reaction of a 4cyanophenyl Mannich base as a vinyl ketone precursor with 4-cyanobenzaldehyde. The synthesis has potential for use in the large scale preparation of the two antimicrobial agents.