Yan Xiao-l
2015
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Journal
Fine Chemical Intermediates
Abstract
2,5-Dichloro-4-aminophenol was synthesized using 1,4-dichlorobenzene as the starting material followed by nitration reaction, catalytic reduction with hydrazine hydrate and Bamberger rearrangement. The optimal reaction conditions for catalytic reduction with hydrazine hydrate and Bamberger rearrangement were evaluated. Under the optimal conditions, the yields of 2,5-dichlorobenzene hydroxylamine and 2,5-dichloro-4-aminophenol were 96.1% and 53.1%, respectively. The synthetic process was proved to be with many advantages including mild reaction conditions, high yield, and simple treatment for products.