Lin Yuan-bin
2007
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Journal
Fine Chemical Intermediates
Abstract
A new route to produce 2,5-dimethoxy phenethylamine was introduced in the paper. Under the basic condition,1,4-dihydroxy benzene was reacted with dimethyl sulfate to get 1,4-dimethoxy benzene with 95.0% of the yield. 1,4-dimethoxy benzene was brominated with high-selective bromating agent to produce 1,4-dimethoxy benzene bromide with 90% of yield. 2,5-dimethoxy phenethanol was synthesized from 1,4-dimethoxy benzene bromide through Grignard reaction and hydroxyethylation(the yield 75.0%),and esterification(the yield 97.0%) and Gabriel reaction(the yield 70.0%). Though there are five steps in this route,but the conditions are mild and easy to carry out,so it is of extensive industrial perspective.