He Chao-hong
2005
Citations
0
Influential Citations
1
Citations
Journal
Journal of Chemical Engineering of Chinese Universities
Abstract
dimethyl-4-hydroxy-3(2H)-furanone (Furaneol) is one of the important products in the flavor industry. Using the chemical reaction route selection method proposed by the authors, a reaction route of using commercial methylglyoxal as the starting material to produce Furaneol was chosen. Through a coupling reaction of methylglyoxal to form intermediate threo-3,4-dihydroxyhexane-2,5-dione at first, the cyclization reaction was followed to form the product Furaneol. The influences of various reaction conditions on the yield were investigated, and the optimum reaction conditions are obtained as follows: (1) Coupling reaction: methylglyoxal 50g in the form of 25%(g?g?1) aqueous solution, glacial acetic acid 50mL diluted into 10.8%( g?g?1) aqueous solution, powdered zinc 36g, reaction temperature 36~38℃, reaction time 2h; (2) Cyclization reaction: the concentration ratio of intermediate threo-3,4-dihydroxyhexane-2,5-dione/disodium, monohydrogenphosphate and side-reaction inhibitor is 0.07g?mL?1:0.27 g?mL?1:0.038 g?mL?1, reaction temperature 70℃ , reaction time 24h. Furthermore, a simple separation process was experimentally determined to successfully purify the Furaneol, thus benefiting the manufacture of Furaneol in industry.