M. Bobko, K. Evans, A. Kaura
Jan 11, 2012
Citations
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Influential Citations
16
Citations
Journal
Tetrahedron Letters
Abstract
An efficient synthesis of 2,5-disubstituted-3-cyanoindoles is described. This approach utilizes a highly selective iodination together with the modified Madelung reaction to generate an intermediate which can be readily transformed to more fully elaborated 2,5-disubstituted-3-cyanoindole templates that were previously difficult to access. Detailed examples and utility of this approach are presented herein.