K. Hemalatha, D. Ilangeswaran
Aug 14, 2020
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Influential Citations
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Journal
Materials Today: Proceedings
Abstract
Abstract An efficient one pot synthesis of 2,6-bis(2/4-hydroxyphenyl)piperidin-4-one have been studied by employing a greener, glucose-urea deep eutectic solvent (DES) as a reaction medium. Usually choline chloride-based DESs are used as a solvent for organic synthesis. In this work, some 2,6-bis(2/4-hydroxyphenyl)piperidin-4-one derivatives were produced using a real greener solvent of glucose-urea DES. Glucose-urea DES does not leave any harmful organic pollutants to the environment during synthesis and hence considered to be a real green solvent. Piperidin-4-one derivatives have found more applications in pharmacological field. Here we report the greener method for the synthesis of 2,6-bis(2/4-hydroxyphenyl) piperidin-4-one derivatives, starting from 2 and 4-hydroxybenzaldehyde with different ketones such as 2-propanone, 2-butanone, 2-pentanone and 3-pentanone in presence of ammonia. All the five compounds (a – e) as given in Scheme 1 synthesised by this method were characterised by FT- IR, 1HNMR and 13CNMR spectral methods. The yields of the products were found to be better as compared to other methods available in the literature. The melting points of the compounds were also determined. Thus, the use of glucose-urea DES as a reaction medium provides advantages in terms of simple synthetic procedure and as well as yields are obtained with good atom economy.