Li Gong-chun
2013
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Journal
Coal and Chemical Industry
Abstract
In order to prepare 2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylic acid,firstly,by Hantzsch reaction,diethyl 1,4-dihydro-2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylate was prepared by 0.10 mol benzaldehyde,0.25 mol ethyl acetoacetate and 0.125 mol ammonium bicarbonate,refluxing 0.5 h in the solvent of 40 mL methanol.Under the condition of stirring,the yield was 45.9%.Secondly,0.01 mol diethyl 1,4-dihydro-2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylate and 0.02 mmol ferric chloride hexahydrate was added to the reaction system to form the corresponding aromatization diethyl 2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylate under refluxing condition,the yield was 50.2%.Finally the product was synthesized by hydrolyzation,the yield was 62.7%.