T. Hiyama, Noriko Wakasa, Tomoko Ueda
Feb 1, 1990
Citations
0
Influential Citations
32
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
A facile and practical method for the synthesis of 2-(6-methoxy-2-naphthyl)propenoic acid, a precursor of anti-inflammatory agent naproxen, is described. The method involves (1) Pd-catalyzed ethynylation of 2-bromo-6-methoxynaphthalene, (2) regioselective addition of HX to the triple bond, and (3) Pd-catalyzed carbonylation of the resulting vinyl halide followed by (4) alkaline hydrolysis.