Chen Guo-liang
2006
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Journal
Journal of Shenyang Pharmaceutical University
Abstract
Objective To prepare 2-amino-1,3-propanediol.Methods The target compound was synthesized with malonic acid diethyl ester as the starting material by nitrosation and reduction with Na-ethanol.Results and Conclusions The desired product is obtained in total yield of 53.5% and its structure is confirmed by()~1H-NMR.In this route,the overall cost is low and the reaction condition is temperate,so it is suitable for the industrial production.