H. Ai
2002
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Amino 2 (5 bromo 6 methoxy 2 naphthyl) propionic acid, the intermediate of naproxen, was synthesized by bromination of 2 methoxynaphthalene with 1,3 dibromo 5,5 dimethyl hydantoin (DBDMH) in the presence of a catalytic amount of hydrochloric acid in acetone with the yield of 96% within 8 min, acylation, Bucherer Berg's reaction and hydrolysis. The reaction condition of the Bucherer Berg's reaction was optimized. The overall yield was 68%.