A. Ayi, R. Guedj
Feb 1, 1984
Citations
0
Influential Citations
5
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract The synthesis of some 2-amino-3-fluoro-nitriles and 2-amino-3-fluoro-acids and their esters have been achieved by means of a Strecker-type reaction. The method involved the action of amines with 3-fluoro-2-hydroxy-nitriles followed by acid solvolysis. The first step has been found to be stereospecific leading to the 2-amino-3-fluoronitriles with inversion of configuration at the carbon atom carrying hydroxyl.