Jiang Jian-hui
2010
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Journal
Journal of Anhui Agricultural Sciences
Abstract
[Objective] To investigate a novel synthesis method of 2-amino-4-methoxy benzoic acid.[Method] Toluidine was used as the starting material to synthesize 2-amino-4-methoxy benzoic acid through nitrification,diazotization,methylation,oxidation,selective reduction approach.The intermediate and final products were identified with 1H NMR,13C NMR,IR and MS.[Result] White powder(56.12 g) melting point 176-178 ℃were identified as 2-amino-4-methoxy benzoic acid by 1H NMR,13C NMR,IR and MS and the yield was 61%.[Conclusion] The synthesis method has more advantages including short synthetic route,readily available raw materials and low cost.