L. Thomas, Archana Gupta, Vandana Gupta
Aug 1, 2003
Citations
0
Influential Citations
29
Citations
Journal
Journal of Fluorine Chemistry
Abstract
The synthesis of 2-amino-5-chloro-3-(trifluoromethyl)benzenethiol was achieved by hydrolytic cleavage of 2-amino-6-chloro-4-(trifluoromethyl)benzothiazole which was prepared by cyclization of 4-chloro-2-(trifluoromethyl)phenylthiourea by bromine in chloroform, the phenylthiourea was prepared by the reaction of 4-chloro-2-(trifluoromethyl)aniline with ammonium thiocyanate in hydrochloric acid. Condensation and oxidative cyclization of 2-amino-5-chloro-3-(trifluoromethyl)benzenethiol with β-diketones/β-ketoesters provided 4H-1,4-benzothiazines. Fluorinated sulfones were obtained by oxidation of the corresponding benzothiazines with 30% hydrogen peroxide in glacial acetic acid. The structures of the newly synthesized compounds were confirmed by spectral studies.