Zhang Zho
2014
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Journal
Fine Chemical Intermediates
Abstract
2-Amino-5-chloro-N,3-dimethylbenzamide was synthesized from 7-methylisatin in overall yield of 62%(purity of 99.6%) by a series of chlorination, oxidation and ammonolysis. The process conditions including the reaction temperature and the reagents ratio of the chlorination and the reaction temperature of the oxidation were optimized.