P. Briner, M. Fyfe, Pierre Martin
Feb 10, 2006
Citations
0
Influential Citations
15
Citations
Journal
Organic Process Research & Development
Abstract
The first synthesis of 2-amino-5-fluorothiazole hydrochloride is reported from 2-aminothiazole. The synthesis proceeds in 35% overall yield, involves no chromatographic purification, and has been employed to prepare multikilogram quantities of the title compound. The key fluorine-introducing step comprises the reaction of dilithiated 2-tert-butoxycarbonylaminothiazole with N-fluorobenzenesulfonimide.