Song Guo-qiang
2008
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Journal
Chinese Journal of Pharmaceuticals
Abstract
2-Amino-6-methoxy-3-nitropyridine was synthesized from 2,6-dichloro-3-nitropyridine, ammonium hydroxide and methanol in sodium hydroxide solution in one-pot step with an overall yield of 65% and purity of 98%. The following optimized conditions were obtained: the molecular ratio (2.45∶1) for 25% ammonia to the starting material, reaction temperature 110℃ and reaction time 12h.