Min Liu, Meng-Tian Zeng, Wan Xu
Nov 15, 2017
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 2-Aminobenzoxazoles and 2-mercaptobenzoxazoles were selectively synthesized by treating o -aminophenols with dithiocarbamates and tetramethylthiuram disulfide (TMTD), respectively. With the promotion of NaH/CuI, the reaction of o -aminophenols with dithiocarbamates gave 2-aminobenzoxazoles with good yield (70–92%) in one pot manner, and 2-mercaptobenzoxazoles were synthesized (yield: 55–80%) in the presence of K 2 CO 3 by treating o -aminophenols with tetramethylthiuram disulfide (TMTD). The feature of this method includes good to excellent yield, easy performance and broad substrate scope, which makes the protocol practical and attractive in the preparation of some potential pharmaceutically active compounds.