R. Zhao, Stacey Gove, J. Sundeen
Mar 11, 2001
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A new facile method has been developed for the synthesis of 2-aminothiazole-5-carboxylates. The new method involves reaction of ethyl β-ethoxyacrylate with N -bromosuccinimide (NBS) to give a novel intermediate, α-bromo-α-formylacetate hemiacetal. Cyclization of the in situ formed hemiacetal with thioureas afforded 2-aminothiazole-5-carboxylates in 60–98% yields.