Li Ming-zhu
2010
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Influential Citations
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Citations
Quality indicators
Journal
Journal of Medical Science Yanbian University
Abstract
OBJECTIVE To synthesize the 2-(arylamino)ethyl 2-[1-(pyridin-2-yl)eth-oxy] acetate and its effects for ability of memory in mice.METHODS The compounds of 2-(arylamino)ethyl 2-[1-(pyridin-2-yl)ethoxy] acetate(5 a~5 e)were prepared using 2-ethylpyridine,through the Whol-Ziegler reaction,Williamson reaction and esterification,and its effects for ability of memory in mice were studied by swimming maze test.RESULTS The mistake frequency in mice with large and small doses of 2-(phenylamino)ethyl 2-[1-(pyridin-2-yl)ethoxy] acetate(5 a)were significantly decreased as compared with alcohol group,there were a significant different between two groups.CONCLUSION The compound 5 a can facilitate the memory in mice.