D. Flaherty, P. Balse, Ke Li
Feb 1, 1995
Citations
0
Influential Citations
3
Citations
Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
Abstract We prepared 2-azido-1, N6-etheno-2′-deoxyadenosine 5′-monophosphate (7b) by activation of the 2-thio analog 4b by two methods. In the preferred method, 4b was treated with 2,4-dinitrofluorobenzene in 50% aqueous acetonitrile, and the resultant thioether was cleaved with hydrazoic acid, yielding the 2-azido-1, N6-etheno analog 7b in 70% isolated yield. N-bromoacetamide oxidized the etheno group of 7b, giving the 2-azido analog of dAMP 9b in 78% yield.