Zhiqian Guo, Xuehong Wei, Yupeng Hua
Jun 17, 2015
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron Letters
Abstract
A direct transition-metal-free synthesis of 2-benzoylpyrrole derivatives from free (N–H) pyrroles and benzaldehyde has been developed. The benzoylation reaction at the 2 or 5-position of pyrrole proceeded well under the alkali metalation system and with 2,6-dimethylaniline as the additive in moderate to good yields. This strategy offers a simple, efficient approach to synthesis of the 2-benzoylpyrrole derivatives.