Ramdas Lakavath, Veeranna Dharmasothu, Ravi Guguloth
Feb 14, 2022
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Abstract
A series of novel 2-bromo-6-(4,5-diphenyl-1-((subtituted-phenyl-1H-1,2,3-triazol-4-yl)methyl)-1H-imidazol-2-yl)pyridine (7a-l) were synthesized and characterized by various analytical techniques. All the synthesized compounds were evaluated for their in vitro anticancer activity against two human cancer cell lines such as HT-1080 (Human fibro sarcoma cells) and Caco-2(Human colorectal adenocarcinoma cells) and IC50values were compared against standard anticancer drug doxorubicin. Among all the synthesized compounds 7b, 7c and 7f has shown potent activity against HT-1080. Similarly compounds 7b and 7c shown significant activity among all the synthesized compounds against Caco-2. Furthermore, the results were supported by molecular docking studies.