Chen Yu-bin
2008
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To synthesize a key intermediate of eprosartan,2-butyl-5-formylimidazole(1).Methods With ethylenediamine and valeronitrile as raw materials,2-butyl-imidazoline (2) was synthesized in the presence of sulfur,after dehydrogenation,iodination,reduction,hydroxymethylation,oxidation,hydrogenolysis to give 2-butyl-5-formylimidazole.Results and conclusion Aimed compound was synthesized and identified by MS and 1H-NMR.The starting materials in the synthetic route are easily available and this procedure has advantage of convenient operations and mild conditions.The total yield is 10.8%.