Zuo Hang-dong
2010
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Journal
Fine Chemical Intermediates
Abstract
2-Chloro-3-(2',2',2'-trifluoroethoxy)-pyridine(4) is a key intermediate for the synthesis of the highly efficient herbicide trifloxysulfuron.4 was synthesized from nicotinamide(1) via Hofmann degradation,oxidative chlorination and diazotization-alcoholysis.The reaction conditions were optimized and the overall yield of 4 was up to 48.7%(based on nicotinamide).