Binliang Zhang, Yanmi Zhou, Qi Gu
Dec 10, 2019
Citations
0
Influential Citations
0
Citations
Journal
IOP Conference Series: Materials Science and Engineering
Abstract
2-chloro-4-(3-nitrophenoxy)-6-(thiophen-2-yl) pyrimidine (8) is an important intermediate for small molecule anticancer drugs. A rapid and high yield synthetic method for 2-chloro-4-(3-nitrophenoxy)-6-(thiophen-2-yl) pyrimidine (8) was established in this work. The target compound was synthesized from the commercially available pyrimidine-2, 4, 6(1H, 3H, 5H)-trione (5) through three steps including halogenation reaction, coupling reaction and nucleophilic reaction. The structure of the target product was confirmed by 1H NM. In addition, the synthetic method was optimized. The total yield of the three steps was high up to 85%.