Qiu Ji-ping
2007
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Journal
Chemical Intermediates
Abstract
2-Chloro-5-chloromethylpyridine is the key intermediate of insecticide such as imidacloprid and acetamiprid.A synthetic method of direct cyclization was researched that 2-chloro-2-chloromethyl-4-cyanobutyraldehyde was reacted with phosphorus oxychloride to get 2-chloro-5-chloromethylpyridine.The conditions were optimized via orthogonal experiments,a high purity of 2-chloro-5-chloromethylpyridine could be achieved and the purity was above 95%.