G. Ponticello, E. Engelhardt, M. B. Freedman
Oct 21, 1980
Citations
0
Influential Citations
1
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A convenient method for the synthesis of 2-chloro-5-hydroxynicotinonitrile (10) via 5-amino-2-chloro-3-methylpyridine (3) is described. Subsequent conversions provided the basic metabolite 2 of (S)-2-(3-t-butylamino-2-hydroxypropoxy)-3-cyanopyridine (1). 13C Nmr data is also presented to characterize 2-chloro-5-fluoro-3-methylpyridine (5), a by-product in the Schiemann reaction having unexpected 1H and 19F nmr spectra.