Shi Wei-bing
2009
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
2-Chloronicotinic acid(1) in total yield of 75.1% was synthesized from 3-cyanopyridine(2) by the reaction of oxidation,chlorination and hydrolysis.The structure was identified by IR and MS.The appropriate oxidation conditions in yield of 92.2% at 70 ℃ for 8 h were as follows: 2 was 410 mmol;n(H2O2) ∶n(2) was 1.2 ∶1.0.