Nan-Sheng Li, J. Piccirilli
Nov 1, 2005
Citations
0
Influential Citations
4
Citations
Journal
Synthesis
Abstract
2'-Deoxy-2'-C-a-methylribonucleosides provide valuable biochemical probes with which to study RNA structure and function. Using methyl 2-acetoxymethyl-3,5-di-O-(tert-butyldimethylsilyl)-D-ribofuranoside (1) as a glycosylating agent, we achieved in four steps an improved synthesis of 2'-deoxy-2'-C-u-methyladenosine (8) and the first synthesis of 2'-deoxy-C-α-methylguanosine (9) in 25% and 17% overall yield, respectively.