M. Diksic, D. Jolly
Sep 15, 1986
Citations
0
Influential Citations
18
Citations
Journal
Carbohydrate Research
Abstract
Abstract 1,5-Anhydro-2-deoxy- d - arabino - ( d -glucal), 1,5-anhydro-2-deoxy- d - lyxo - ( d -galactal), and 3,4,6-tri- O -acetyl-1,5-anhydro-2-deoxy- d - lyxo -hex-1-enitol (3,4,6-tri- O -acetyl- d -galactal) ( 3 ) were fluorinated in water and organic solvent-water with molecular fluorine and, for 18 F-labelled compounds, with [ 18 F]fluorine. Chemical yields of 40 and 10% were obtained for 2-deoxy-2-fluoro- d -glucose and 2-deoxy-2-fluoro- d -mannose, respectively, and 35 and 5% for 2-deoxy-2-fluoro- d -galactose ( 12 ) and 2-deoxy-2-fluoro- d -talose ( 13 ), respectively. In the fluorination of 3 , the chemical yields of 12 and 13 were 38 and 6%, respectively. An l.c. separation of 2-deoxy-2-fluoro- d -hexoses is described.