J. Desrosiers, C. Kelly, Daniel R Fandrick
Mar 6, 2014
Citations
0
Influential Citations
18
Citations
Journal
Organic letters
Abstract
A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows access to a diverse range of substitution patterns on all positions on the ring system and on the difluoromethyl group.